SIX1

GENERAL INFORMATION

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Gene name

SIX1

Gene description

SIX homeobox 1

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (prostate, salivary gland, skeletal muscle)
GTEx:Tissue enhanced (skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in selected tissues, most abundant in skeletal muscle, respiratory epithelia and salivary gland. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA001893 , CAB058690
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (prostate, salivary gland, skeletal muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skeletal muscle)

Organ

Expression



GENE INFORMATION

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Gene name

SIX1 (HGNC Symbol)

Synonyms

DFNA23

Description

SIX homeobox 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q23.1

Chromosome location (bp)

60643415 - 60658259

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126778 (version 78.38)

Entrez gene

6495

UniProt

Q15475 (UniProt - Evidence at protein level)

neXtProt

NX_Q15475

Antibodypedia

SIX1 antibodies


PROTEIN BROWSER

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ENST00000247182
 
ENST00000554986
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SIX1-001 ENSP00000247182
ENST00000247182
Q15475
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Show » Show » 284 32.2 No 0
SIX1-005 ENSP00000452700
ENST00000554986
H0YK85
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Show » 111 12 No 0