MAP2K2

GENE INFORMATION

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Gene name

MAP2K2 (HGNC Symbol)

Synonyms

MEK2, PRKMK2

Description

mitogen-activated protein kinase kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

4090319 - 4124126

Ensembl

ENSG00000126934 (version 73.37)

Entrez gene

5605

UniProt

P36507 (UniProt - Evidence at protein level)

neXtProt

NX_P36507

Antibodypedia

MAP2K2 antibodies
 

PROTEIN VIEW

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MAP2K2-001
 
MAP2K2-010
 
MAP2K2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K2-001 ENSP00000262948
ENST00000262948
P36507
Show all »
Show » Show » 400 44.4 No 0
MAP2K2-010 ENSP00000471763
ENST00000599021
Show » 104 11.6 No 0
MAP2K2-201 ENSP00000378336
ENST00000394867
G5E9C7
Show all »
Show » 303 33.9 No 0