The Human Protein Atlas

GENE INFORMATION

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Gene name	SMARCA4 (HGNC Symbol)
Synonyms	BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	19 (Chromosome progress)
Cytoband	p13.2
Chromosome location (bp)	11071598 - 11176071
Ensembl	ENSG00000127616 (version 69.37)
Entrez gene	6597
UniProt	P51532
neXtProt	NX_P51532
Antibodypedia	SMARCA4 antibodies

PROTEIN VIEW

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SMARCA4-001		SMARCA4-002		SMARCA4-003		SMARCA4-004		SMARCA4-005		SMARCA4-006		SMARCA4-007		SMARCA4-015		SMARCA4-018		SMARCA4-201		SMARCA4-202		SMARCA4-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
SMARCA4-001	ENSP00000343896 ENST00000344626	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1 A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA B4DSI8 [Target identity:52%; Query identity:100%] cDNA FLJ60344, highly similar to Probable global transcription activator SNF2L4	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1647	184.6	No	0
SMARCA4-002	ENSP00000466963 ENST00000590574	B3KNW7 Show all » « Hide B3KNW7 [Target identity:45%; Query identity:100%] cDNA FLJ30606 fis, clone CTONG2000330, highly similar to Probable global transcription activator SNF2L4	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins		1614	181.3	No	0
SMARCA4-003	ENSP00000392837 ENST00000444061	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1613	181.3	No	0
SMARCA4-004	ENSP00000464778 ENST00000589677		Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins		1616	181.6	No	0
SMARCA4-005	ENSP00000445036 ENST00000541122	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1617	181.7	No	0
SMARCA4-006	ENSP00000443848 ENST00000538456		Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins		427	49.7	No	0
SMARCA4-007	ENSP00000395654 ENST00000429416	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1 A7E2E1 [Target identity:100%; Query identity:100%] SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_a; cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA B4DSI8 [Target identity:52%; Query identity:100%] cDNA FLJ60344, highly similar to Probable global transcription activator SNF2L4	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1647	184.6	No	0
SMARCA4-015	ENSP00000467796 ENST00000586985				113	12.6	No	0
SMARCA4-018	ENSP00000467200 ENST00000592158				136	15.7	No	0
SMARCA4-201	ENSP00000350720 ENST00000358026	Q9HBD4 Show all » « Hide Q9HBD4 [Target identity:100%; Query identity:100%] SMARCA4 isoform 2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4, isoform CRA_c; Transcription activator BRG1	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000792 [heterochromatin] GO:0000902 [cell morphogenesis] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001570 [vasculogenesis] GO:0001701 [in utero embryonic development] GO:0001832 [blastocyst growth] GO:0001835 [blastocyst hatching] GO:0001889 [liver development] GO:0003682 [chromatin binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005625 [soluble fraction] GO:0005634 [nucleus] GO:0005719 [nuclear euchromatin] GO:0005726 [perichromatin fibrils] GO:0006338 [chromatin remodeling] GO:0006346 [methylation-dependent chromatin silencing] GO:0007399 [nervous system development] GO:0007403 [glial cell fate determination] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0010424 [DNA methylation on cytosine within a CG sequence] GO:0016514 [SWI/SNF complex] GO:0019827 [stem cell maintenance] GO:0030198 [extracellular matrix organization] GO:0030216 [keratinocyte differentiation] GO:0030900 [forebrain development] GO:0030902 [hindbrain development] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035887 [aortic smooth muscle cell differentiation] GO:0043388 [positive regulation of DNA binding] GO:0043966 [histone H3 acetylation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048562 [embryonic organ morphogenesis] GO:0048730 [epidermis morphogenesis] GO:0060318 [definitive erythrocyte differentiation] GO:0060347 [heart trabecula formation] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex]	1679	188.1	No	0
SMARCA4-202	ENSP00000414727 ENST00000413806	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1617	181.7	No	0
SMARCA4-203	ENSP00000397783 ENST00000450717	P51532 Show all » « Hide P51532 [Direct mapping] Transcription activator BRG1	Show » « Hide Potential transmembrane proteins SPOCTOPUS predicted membrane proteins Mapped to UniProt SWISS-PROT UniProt - Evidence at protein level	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0002039 [p53 binding] GO:0003407 [neural retina development] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006337 [nucleosome disassembly] GO:0006338 [chromatin remodeling] GO:0006351 [transcription, DNA-dependent] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008094 [DNA-dependent ATPase activity] GO:0016514 [SWI/SNF complex] GO:0030308 [negative regulation of cell growth] GO:0030957 [Tat protein binding] GO:0043923 [positive regulation by host of viral transcription] GO:0045749 [negative regulation of S phase of mitotic cell cycle] GO:0045892 [negative regulation of transcription, DNA-dependent] GO:0045893 [positive regulation of transcription, DNA-dependent] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0050681 [androgen receptor binding] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0070577 [histone acetyl-lysine binding] GO:0071564 [npBAF complex] GO:0071565 [nBAF complex] GO:0071778 [WINAC complex]	1616	181.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.