SMARCA4

GENE INFORMATION

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Gene name

SMARCA4 (HGNC Symbol)

Synonyms

BAF190, BRG1, FLJ39786, hSNF2b, SNF2, SNF2-BETA, SNF2L4, SNF2LB, SWI2

Description

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

11071598 - 11176071

Ensembl

ENSG00000127616 (version 73.37)

Entrez gene

6597

UniProt

P51532 (UniProt - Evidence at protein level)

neXtProt

NX_P51532

Antibodypedia

SMARCA4 antibodies
 

PROTEIN VIEW

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SMARCA4-001
 
SMARCA4-002
 
SMARCA4-003
 
SMARCA4-004
 
SMARCA4-005
 
SMARCA4-006
 
SMARCA4-007
 
SMARCA4-015
 
SMARCA4-018
 
SMARCA4-201
 
SMARCA4-202
 
SMARCA4-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMARCA4-001 ENSP00000343896
ENST00000344626
P51532
Show all »
Show » Show » 1647 184.6 No 0
SMARCA4-002 ENSP00000466963
ENST00000590574
P51532
Show all »
Show » Show » 1614 181.3 No 0
SMARCA4-003 ENSP00000392837
ENST00000444061
P51532
Show all »
Show » Show » 1613 181.3 No 0
SMARCA4-004 ENSP00000464778
ENST00000589677
P51532
Show all »
Show » Show » 1616 181.6 No 0
SMARCA4-005 ENSP00000445036
ENST00000541122
P51532
Show all »
Show » Show » 1617 181.7 No 0
SMARCA4-006 ENSP00000443848
ENST00000538456
H0YGM3
Show all »
Show » Show » 427 49.7 No 0
SMARCA4-007 ENSP00000395654
ENST00000429416
P51532
Show all »
Show » Show » 1647 184.6 No 0
SMARCA4-015 ENSP00000467796
ENST00000586985
Show » 113 12.6 No 0
SMARCA4-018 ENSP00000467200
ENST00000592158
K7EP28
Show all »
Show » 136 15.7 No 0
SMARCA4-201 ENSP00000350720
ENST00000358026
Q9HBD4
Show all »
Show » Show » 1679 188.1 No 0
SMARCA4-202 ENSP00000414727
ENST00000413806
P51532
Show all »
Show » Show » 1617 181.7 No 0
SMARCA4-203 ENSP00000397783
ENST00000450717
P51532
Show all »
Show » Show » 1616 181.6 No 0