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GENE INFORMATION

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Gene name

HIP1 (HGNC Symbol)

Synonyms

ILWEQ

Description

huntingtin interacting protein 1 (HGNC Symbol)

Entrez gene summary

The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

7 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

75162621 - 75368280

Ensembl

ENSG00000127946 (version 69.37)

Entrez gene

3092

UniProt

O00291

neXtProt

NX_O00291

Antibodypedia

HIP1 antibodies
 

PROTEIN VIEW

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HIP1-001
 
HIP1-002
 
HIP1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIP1-001 ENSP00000336747
ENST00000336926
O00291
Show all »
Show » Show » 1037 116.2 No 0
HIP1-002 ENSP00000410300
ENST00000434438
E7ES17
Show all »
Show » Show » 986 110.7 No 0
HIP1-004 ENSP00000414280
ENST00000420909
C9JMG5
Show all »
Show » Show » 146 16.9 No 0