KDR

GENE INFORMATION

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Gene name

KDR (HGNC Symbol)

Synonyms

CD309, FLK1, VEGFR, VEGFR2

Description

kinase insert domain receptor (a type III receptor tyrosine kinase) (HGNC Symbol)

Entrez gene summary

Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]

Chromosome

4 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

55944644 - 55991756

Ensembl

ENSG00000128052 (version 73.37)

Entrez gene

3791

UniProt

P35968 (UniProt - Evidence at protein level)

neXtProt

NX_P35968

Antibodypedia

KDR antibodies
 

PROTEIN VIEW

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KDR-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KDR-001 ENSP00000263923
ENST00000263923
P35968
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