DGCR8

GENERAL INFORMATION

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Gene name

DGCR8

Gene description

DGCR8 microprocessor complex subunit

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

A majority of normal tissues displayed moderate to strong cytoplasmic positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA019965
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DGCR8 (HGNC Symbol)

Synonyms

C22orf12, DGCRK6, Gy1, pasha

Description

DGCR8 microprocessor complex subunit (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

20080232 - 20111877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128191 (version 78.38)

Entrez gene

54487

UniProt

Q8WYQ5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WYQ5

Antibodypedia

DGCR8 antibodies


PROTEIN BROWSER

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ENST00000351989
 
ENST00000383024
 
ENST00000407755
 
ENST00000457069
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DGCR8-001 ENSP00000263209
ENST00000351989
Q8WYQ5
Show all »
Show » Show » 773 86 No 0
DGCR8-003 ENSP00000384726
ENST00000407755
Q8WYQ5
Show all »
Show » Show » 740 82.7 No 0
DGCR8-009 ENSP00000409625
ENST00000457069
C9JSD5
Show all »
Show » 125 13.2 No 0
DGCR8-201 ENSP00000372488
ENST00000383024
Q8WYQ5
Show all »
Show » Show » 740 82.7 No 0