ADORA2A

GENE INFORMATION

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Gene name

ADORA2A (HGNC Symbol)

Synonyms

ADORA2, RDC8

Description

adenosine A2a receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]

Chromosome

22 (Chromosome progress)

Cytoband

q11.23

Chromosome location (bp)

24813847 - 24838328

Ensembl

ENSG00000128271 (version 73.37)

Entrez gene

135

UniProt

P29274 (UniProt - Evidence at protein level)

neXtProt

NX_P29274

Antibodypedia

ADORA2A antibodies
 

PROTEIN VIEW

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ADORA2A-001
 
ADORA2A-002
 
ADORA2A-003
 
ADORA2A-005
 
ADORA2A-008
 
ADORA2A-009
 
ADORA2A-011
 
ADORA2A-012
 
ADORA2A-015
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADORA2A-001 ENSP00000336630
ENST00000337539
P29274
Show all »
Show » Show » 412 44.7 No 7
ADORA2A-002 ENSP00000474097
ENST00000496258
C9J0Z4
Show all »
Show » Show » 83 8.7 No 2
ADORA2A-003 ENSP00000404497
ENST00000424232
C9JFS2
Show all »
Show » Show » 88 9.2 No 2
ADORA2A-005 ENSP00000414802
ENST00000444262
C9JQD8
Show all »
Show » Show » 365 40.1 No 7
ADORA2A-008 ENSP00000474895
ENST00000464977
6 0.6 No 0
ADORA2A-009 ENSP00000473799
ENST00000486108
C9JFS2
Show all »
Show » Show » 108 11.5 No 3
ADORA2A-011 ENSP00000475000
ENST00000472248
Show » 29 3.1 No 1
ADORA2A-012 ENSP00000400190
ENST00000439591
C9J0Z4
Show all »
Show » Show » 76 7.9 No 2
ADORA2A-015 ENSP00000397071
ENST00000436735
C9J3T2
Show all »
Show » Show » 64 6.7 No 2