ATF4

GENE INFORMATION

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Gene name

ATF4 (HGNC Symbol)

Synonyms

CREB-2, TAXREB67, TXREB

Description

activating transcription factor 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]

Chromosome

22 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

39915700 - 39918691

Ensembl

ENSG00000128272 (version 73.37)

Entrez gene

468

UniProt

P18848 (UniProt - Evidence at protein level)

neXtProt

NX_P18848

Antibodypedia

ATF4 antibodies
 

PROTEIN VIEW

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ATF4-001
 
ATF4-002
 
ATF4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF4-001 ENSP00000384587
ENST00000404241
P18848
Show all »
Show » Show » 351 38.6 No 0
ATF4-002 ENSP00000336790
ENST00000337304
P18848
Show all »
Show » Show » 351 38.6 No 0
ATF4-201 ENSP00000379912
ENST00000396680
P18848
Show all »
Show » Show » 351 38.6 No 0