The Human Protein Atlas

ABOUT & HELP

GENE: LIF

SUMMARY

INFO

GENE/PROTEIN ANTIBODY/ANTIGEN

EXPRESSION

SUBCELLULAR LOCATION NORMAL TISSUE CANCER TISSUE

CELL LINE

RNA

Fields »

ANDNOT

Field

All —Gene nameProtein classChromosomeExternal id —Subcellular location (IF)Organ expression (IH)Tissue expression (IH)Cancer expression (IH)Cell expression (IH) —IH validationIF validationWB validationPA validation —Evidence summaryUniProt evidenceHPA evidenceRNA evidence —With antibodiesWith annotated expression (IH)With annotated expression (IF) —Sort by

Term

Gene name

Class

KinasesCD markersBlood group antigen proteinsTransportersRibosomal proteinsPeptidasesCandidate cancer biomarkersG-protein coupled receptorsPlasma proteinsCandidate cardiovascular disease genesTranscription factorsEnzymesSH2-domain containing proteinsSH3-domain containing proteinsMutated genes in cancerVoltage-gated ion channelsPotential transmembrane proteinsPotentially secreted proteinsMapped to UniProt SWISS-PROT

Subclass

Chromosome

12345678910111213141516171819202122MTUnmappedXY

External id

Location

Nucleus Nucleoli Nucleus but not nucleoli Nuclear membrane Plasma membrane Cytoplasm Mitochondria Endoplasmic reticulum Golgi apparatus Vesicles Microtubule organizing center Cytoskeleton Cytoskeleton (Actin filaments) Cytoskeleton (Intermediate filaments) Cytoskeleton (Microtubules) Cytoskeleton (Cytokinetic bridge) Centrosome Extracellular matrix Focal Adhesions Cell Junctions Aggresome

Organ

AnyCentral nervous system (Brain)Blood and immune system (Hematopoietic)Liver and pancreasDigestive tract (GI-tract)Respiratory system (Lung)Cardiovascular system (Heart and blood vessels)Breast and female reproductive system (Female tissues)PlacentaMale reproductive system (Male tissues)Urinary tract (Kidney and bladder)Skin and soft tissuesEndocrine glands

Fraction

><=

tissues

0%5%10%15%20%25%30%35%40%45%50%55%60%65%70%75%80%85%90%95%100%

Expression

Negative Weak Moderate Strong

Tissue

AnyAdrenal glandAppendixBone marrowBreastBronchusCerebellumCerebral cortexCervix, uterineColonDuodenumEpididymisEsophagusFallopian tubeGallbladderHeart muscleHippocampusKidneyLateral ventricleLiverLungLymph nodeNasopharynxOral mucosaOvaryPancreasParathyroid glandPlacentaProstateRectumSalivary glandSeminal vesicleSkeletal muscleSkinSmall intestineSmooth muscleSoft tissue 1Soft tissue 2SpleenStomach, lowerStomach, upperTestisThyroid glandTonsilUrinary bladderUterus, post-menopauseUterus, pre-menopauseVaginaVulva/anal skin

Cell type

Expression

Negative Weak Moderate Strong

Tissue

AnyBreast cancerCarcinoidCervical cancerColorectal cancerEndometrial cancerGliomaHead and neck cancerLiver cancerLung cancerLymphomaMelanomaOvarian cancerPancreatic cancerProstate cancerRenal cancerSkin cancerStomach cancerTestis cancerThyroid cancerUrothelial cancer

Fraction

><=

patients

0%5%10%15%20%25%30%35%40%45%50%55%60%65%70%75%80%85%90%95%100%

Expression

Negative Weak Moderate Strong

Cell	Expression Negative Weak Moderate Strong

Validation

Supportive Uncertain Non-supportive

Validation

Supportive Uncertain Non-supportive

Validation

Supportive Uncertain Non-supportive

Validation

Supportive Uncertain Non-supportive

Category

High Medium Low Only RNA None

Score

Class 1 Class 2 Class 3-5

Score

High Medium Low Very low

Score

High Medium Low Not detected

Antibodies

YesNo

Annotated expression

YesNo

Annotated expression

YesNo

Column

geneposition

Cell line HDLM-2

? »

The cell detail page shows the stained cells from the selected cell line/cell sample using the antibody/antibodies.

The automatic annotation is done for duplicate samples for each antibody. The area/cells buttons can be used to mark the areas and cells that have been detected. The assay and annotation is described here.

By clicking on an image, an enlarged view of that image will open. The area and cell overlay images can be visualised and the image can be panned.

	Antibody HPA018844
Image
Antibody staining
Intensity	Weak
Number of cells	203
Fraction positive cells	75 %
Gender	Male
Age	74
Cell line	31


Level of antibody staining
	Strong Moderate Weak Negative

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.