DOCK4

GENERAL INFORMATION

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Gene name

DOCK4

Gene description

Dedicator of cytokinesis 4

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DOCK4 (HGNC Symbol)

Synonyms

FLJ34238, KIAA0716

Description

Dedicator of cytokinesis 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q31.1

Chromosome location (bp)

111726110 - 112206411

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128512 (version 78.38)

Entrez gene

9732

UniProt

Q8N1I0 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N1I0

Antibodypedia

DOCK4 antibodies


PROTEIN BROWSER

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ENST00000417165
 
ENST00000423057
 
ENST00000428084
 
ENST00000437129
 
ENST00000437633
 
ENST00000445943
 
ENST00000450156
 
ENST00000494651
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOCK4-001 ENSP00000404179
ENST00000437633
Q8N1I0
Show all »
Show » Show » 1966 225.2 No 0
DOCK4-004 ENSP00000397412
ENST00000445943
Q75MU6
Show all »
Show » Show » 1999 228.5 No 0
DOCK4-005 ENSP00000410746
ENST00000428084
Q8N1I0
Show all »
Show » Show » 1975 226.2 No 0
DOCK4-007 ENSP00000412834
ENST00000423057
Q75MU6
Show all »
Show » Show » 1389 158.9 No 0
DOCK4-010 ENSP00000403504
ENST00000417165
C9JDB3
Show all »
Show » Show » 131 15.4 No 0
DOCK4-012 ENSP00000406468
ENST00000450156
C9J637
Show all »
Show » Show » 188 22.8 No 0
DOCK4-013 ENSP00000406298
ENST00000437129
C9J7D9
Show all »
Show » Show » 193 23.5 No 0
DOCK4-201 ENSP00000440944
ENST00000494651
Q149N2
Show all »
Show » Show » 1094 126.1 No 0