ATP6V1F

GENE INFORMATION

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Gene name

ATP6V1F (HGNC Symbol)

Synonyms

ATP6S14, VATF, Vma7

Description

ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

128502880 - 128505898

Ensembl

ENSG00000128524 (version 73.37)

Entrez gene

9296

UniProt

Q16864 (UniProt - Evidence at protein level)

neXtProt

NX_Q16864

Antibodypedia

ATP6V1F antibodies
 

PROTEIN VIEW

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ATP6V1F-001
 
ATP6V1F-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1F-001 ENSP00000249289
ENST00000249289
Q16864
Show all »
Show » Show » 119 13.4 No 0
ATP6V1F-002 ENSP00000417378
ENST00000492758
Q16864
Show all »
Show » Show » 147 16.4 No 0