FOXP2

GENE INFORMATION

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Gene name

FOXP2 (HGNC Symbol)

Synonyms

CAGH44, SPCH1, TNRC10

Description

forkhead box P2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Chromosome

7 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

113726382 - 114333827

Ensembl

ENSG00000128573 (version 73.37)

Entrez gene

93986

UniProt

O15409 (UniProt - Evidence at protein level)

neXtProt

NX_O15409

Antibodypedia

FOXP2 antibodies
 

PROTEIN VIEW

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 « 
 
FOXP2-001
 
FOXP2-002
 
FOXP2-004
 
FOXP2-005
 
FOXP2-006
 
FOXP2-007
 
FOXP2-008
 
FOXP2-010
 
FOXP2-014
 
FOXP2-015
 
FOXP2-016
 
FOXP2-017
 
FOXP2-018
 
FOXP2-020
 
FOXP2-201
 
FOXP2-202
 
FOXP2-203
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXP2-001 ENSP00000265436
ENST00000350908
O15409
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Show » Show » 715 79.9 No 0
FOXP2-002 ENSP00000395552
ENST00000440349
F8WDL6
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82 8.7 No 0
FOXP2-004 ENSP00000386200
ENST00000408937
O15409
Show all »
Show » Show » 740 82.6 No 0
FOXP2-005 ENSP00000377135
ENST00000393498
A8MUV4
Show all »
Show » Show » 694 77.2 No 0
FOXP2-006 ENSP00000405470
ENST00000412402
O15409
Show all »
Show » Show » 87 9.4 No 0
FOXP2-007 ENSP00000418100
ENST00000462331
Q75MZ5
Show all »
67 7.2 No 0
FOXP2-008 ENSP00000416825
ENST00000441290
O15409
Show all »
Show » Show » 87 9.4 No 0
FOXP2-010 ENSP00000367482
ENST00000378237
O15409
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Show » Show » 365 41 No 0
FOXP2-014 ENSP00000377132
ENST00000393494
O15409
Show all »
Show » Show » 715 79.9 No 0
FOXP2-015 ENSP00000409826
ENST00000452963
C9JQP8
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205 23.7 No 0
FOXP2-016 ENSP00000375084
ENST00000390668
Q8N6B5
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Show » 456 51.3 No 0
FOXP2-017 ENSP00000353367
ENST00000360232
O15409
Show all »
Show » Show » 432 48.8 No 0
FOXP2-018 ENSP00000377133
ENST00000393495
A8MTU2
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171 18.5 No 0
FOXP2-020 ENSP00000377129
ENST00000393489
O15409
Show all »
Show » Show » 623 70.1 No 0
FOXP2-201 ENSP00000377130
ENST00000393491
Q0PRL4
Show all »
Show » Show » 530 59.9 No 0
FOXP2-202 ENSP00000377137
ENST00000393500
E9PHJ5
Show all »
Show » 382 43.9 No 0
FOXP2-203 ENSP00000385069
ENST00000403559
O15409
Show all »
Show » Show » 732 81.8 No 0