SMO

GENERAL INFORMATION

? »

Gene name

SMO

Gene description

Smoothened, frizzled class receptor

Protein class

Cancer-related genes
FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic staining. Cytotrophoblasts and cilia of the placenta showed strong staining. Cells in seminiferus ducts of the testis showed strong cytoplasmic staining while a subset of Leydig cells displayed strong cytoplasmic and membranous staining. Lymphoid tissues were negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB011446
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

SMO (HGNC Symbol)

Synonyms

FZD11, SMOH

Description

Smoothened, frizzled class receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

129188872 - 129213545

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128602 (version 78.38)

Entrez gene

6608

UniProt

Q99835 (UniProt - Evidence at protein level)

neXtProt

NX_Q99835

Antibodypedia

SMO antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000249373
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMO-001 ENSP00000249373
ENST00000249373
Q99835
Show all »
Show » Show » 787 86.4 Yes 7