MRPS12

GENE INFORMATION

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Gene name

MRPS12 (HGNC Symbol)

Synonyms

RPMS12, RPS12, RPSM12

Description

mitochondrial ribosomal protein S12 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

39421188 - 39423802

Ensembl

ENSG00000128626 (version 73.37)

Entrez gene

6183

UniProt

O15235 (UniProt - Evidence at protein level)

neXtProt

NX_O15235

Antibodypedia

MRPS12 antibodies
 

PROTEIN VIEW

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MRPS12-001
 
MRPS12-002
 
MRPS12-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPS12-001 ENSP00000308845
ENST00000308018
O15235
Show all »
Show » Show » 138 15.2 No 0
MRPS12-002 ENSP00000384952
ENST00000407800
O15235
Show all »
Show » Show » 138 15.2 No 0
MRPS12-004 ENSP00000384579
ENST00000402029
O15235
Show all »
Show » Show » 138 15.2 No 0