HERC2

GENE INFORMATION

? »

Gene name

HERC2 (HGNC Symbol)

Synonyms

D15F37S1, jdf2, p528

Description

HECT and RLD domain containing E3 ubiquitin protein ligase 2 (HGNC Symbol)

Entrez gene summary

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]

Chromosome

15 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

28356186 - 28567298

Ensembl

ENSG00000128731 (version 73.37)

Entrez gene

8924

UniProt

O95714 (UniProt - Evidence at protein level)

neXtProt

NX_O95714

Antibodypedia

HERC2 antibodies
 

PROTEIN VIEW

? »
 
 
 
HERC2-001
 
HERC2-003
 
HERC2-011
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HERC2-001 ENSP00000261609
ENST00000261609
O95714
Show all »
Show » Show » 4834 527.2 No 1
HERC2-003 ENSP00000456237
ENST00000564734
H3BRG9
Show all »
80 8.9 No 0
HERC2-011 ENSP00000457745
ENST00000569772
Show » 200 20.6 No 0