PSMA1

GENE INFORMATION

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Gene name

PSMA1 (HGNC Symbol)

Synonyms

HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30

Description

proteasome (prosome, macropain) subunit, alpha type, 1 (HGNC Symbol)

Entrez gene summary

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Chromosome

11 (Chromosome progress)

Cytoband

p15.2

Chromosome location (bp)

14515329 - 14665181

Ensembl

ENSG00000129084 (version 73.37)

Entrez gene

5682

UniProt

P25786 (UniProt - Evidence at protein level)

neXtProt

NX_P25786

Antibodypedia

PSMA1 antibodies
 

PROTEIN VIEW

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PSMA1-001
 
PSMA1-002
 
PSMA1-004
 
PSMA1-009
 
PSMA1-010
 
PSMA1-201
 
PSMA1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMA1-001 ENSP00000379676
ENST00000396394
P25786
Show all »
Show » Show » 263 29.6 No 0
PSMA1-002 ENSP00000414359
ENST00000418988
P25786
Show all »
Show » Show » 269 30.2 No 0
PSMA1-004 ENSP00000441166
ENST00000530457
F5GX11
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Show » 238 26.5 No 0
PSMA1-009 ENSP00000439724
ENST00000533068
14 1.4 No 0
PSMA1-010 ENSP00000439080
ENST00000532256
2 0.3 No 0
PSMA1-201 ENSP00000379675
ENST00000396393
P25786
Show all »
Show » Show » 263 29.6 No 0
PSMA1-202 ENSP00000392242
ENST00000419365
B4DEV8
Show all »
Show » Show » 164 18.5 No 0