BCL2L2

GENE INFORMATION

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Gene name

BCL2L2 (HGNC Symbol)

Synonyms

BCL-W, KIAA0271, PPP1R51

Description

BCL2-like 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

Chromosome

14 (Chromosome progress)

Cytoband

q11.2

Chromosome location (bp)

23767999 - 23780968

Ensembl

ENSG00000129473 (version 73.37)

Entrez gene

599

UniProt

Q92843 (UniProt - Evidence at protein level)

neXtProt

NX_Q92843

Antibodypedia

BCL2L2 antibodies
 

PROTEIN VIEW

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BCL2L2-001
 
BCL2L2-002
 
BCL2L2-003
 
BCL2L2-004
 
BCL2L2-005
 
BCL2L2-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L2-001 ENSP00000250405
ENST00000250405
Q92843
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Show » Show » 193 20.7 No 2
BCL2L2-002 ENSP00000451148
ENST00000553824
G3V3B7
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Show » 51 5.2 No 0
BCL2L2-003 ENSP00000451701
ENST00000557236
G3V4B7
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Show » Show » 149 16.2 No 0
BCL2L2-004 ENSP00000452265
ENST00000557579
G3V5A9
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Show » Show » 144 15.7 No 0
BCL2L2-005 ENSP00000451234
ENST00000554635
G3V3G8
Show all »
Show » 72 7.7 No 0
BCL2L2-006 ENSP00000451197
ENST00000556599
Show » Show » 167 18.1 No 2