PARP2

GENERAL INFORMATION

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Gene name

PARP2

Gene description

Poly (ADP-ribose) polymerase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and nucleolar expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
HPA052003
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PARP2 (HGNC Symbol)

Synonyms

ADPRTL2

Description

Poly (ADP-ribose) polymerase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

20343582 - 20357905

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129484 (version 78.38)

Entrez gene

10038

UniProt

Q9UGN5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UGN5

Antibodypedia

PARP2 antibodies


PROTEIN BROWSER

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ENST00000250416
 
ENST00000429687
 
ENST00000527915
 
ENST00000539930
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PARP2-001 ENSP00000392972
ENST00000429687
Q9UGN5
Show all »
Show » Show » 570 64.8 No 0
PARP2-002 ENSP00000250416
ENST00000250416
Q9UGN5
Show all »
Show » Show » 583 66.2 No 0
PARP2-003 ENSP00000432283
ENST00000527915
G3V167
Show all »
Show » Show » 531 60.2 No 0
PARP2-013 ENSP00000445524
ENST00000539930
Show » Show » 177 20.3 No 0