AANAT

GENE INFORMATION

? »

Gene name

AANAT (HGNC Symbol)

Synonyms

SNAT

Description

aralkylamine N-acetyltransferase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

17 (Chromosome progress)

Cytoband

q25.1

Chromosome location (bp)

74449433 - 74466199

Ensembl

ENSG00000129673 (version 73.37)

Entrez gene

15

UniProt

Q16613 (UniProt - Evidence at protein level)

neXtProt

NX_Q16613

Antibodypedia

AANAT antibodies
 

PROTEIN VIEW

? »
 
 
 
AANAT-001
 
AANAT-002
 
AANAT-003
 
AANAT-004
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AANAT-001 ENSP00000250615
ENST00000250615
J3KMZ5
Show all »
Show » 252 28.4 No 0
AANAT-002 ENSP00000376282
ENST00000392492
Q16613
Show all »
Show » Show » 207 23.3 No 0
AANAT-003 ENSP00000468239
ENST00000587798
K7ERF6
Show all »
92 10.1 No 0
AANAT-004 ENSP00000468717
ENST00000585649
K7ESH7
Show all »
152 17.2 Yes 0