ARHGEF6

GENE INFORMATION

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Gene name

ARHGEF6 (HGNC Symbol)

Synonyms

alpha-PIX, alphaPIX, Cool-2, Cool2, KIAA0006, MRX46

Description

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (HGNC Symbol)

Entrez gene summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q26.3

Chromosome location (bp)

135747706 - 135864247

Ensembl

ENSG00000129675 (version 73.37)

Entrez gene

9459

UniProt

Q15052 (UniProt - Evidence at protein level)

neXtProt

NX_Q15052

Antibodypedia

ARHGEF6 antibodies
 

PROTEIN VIEW

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ARHGEF6-001
 
ARHGEF6-002
 
ARHGEF6-003
 
ARHGEF6-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARHGEF6-001 ENSP00000250617
ENST00000250617
Q15052
Show all »
Show » Show » 776 87.5 No 0
ARHGEF6-002 ENSP00000359656
ENST00000370622
Q15052
Show all »
Show » Show » 622 70.8 No 0
ARHGEF6-003 ENSP00000359654
ENST00000370620
Q15052
Show all »
Show » Show » 622 70.8 No 0
ARHGEF6-201 ENSP00000439483
ENST00000535227
B7Z3C7
Show all »
Show » Show » 649 73.5 No 0