CDKN1C

GENE INFORMATION

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Gene name

CDKN1C (HGNC Symbol)

Synonyms

BWCR, BWS, KIP2, P57

Description

cyclin-dependent kinase inhibitor 1C (p57, Kip2) (HGNC Symbol)

Entrez gene summary

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

11 (Chromosome progress)

Cytoband

p15.4

Chromosome location (bp)

2904443 - 2907111

Ensembl

ENSG00000129757 (version 73.37)

Entrez gene

1028

UniProt

P49918 (UniProt - Evidence at protein level)

neXtProt

NX_P49918

Antibodypedia

CDKN1C antibodies
 

PROTEIN VIEW

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CDKN1C-001
 
CDKN1C-002
 
CDKN1C-003
 
CDKN1C-006
 
CDKN1C-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN1C-001 ENSP00000413720
ENST00000414822
P49918
Show all »
Show » Show » 316 32.2 No 0
CDKN1C-002 ENSP00000370101
ENST00000380725
A6NK88
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Show » 131 15.1 No 0
CDKN1C-003 ENSP00000411257
ENST00000440480
P49918
Show all »
Show » Show » 305 31 No 0
CDKN1C-006 ENSP00000411552
ENST00000430149
P49918
Show all »
Show » Show » 316 32.2 No 0
CDKN1C-201 ENSP00000321019
ENST00000313407
P49918
Show all »
Show » Show » 305 31 No 0