TNNI3

GENE INFORMATION

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Gene name

TNNI3 (HGNC Symbol)

Synonyms

CMH7, TNNC1

Description

troponin I type 3 (cardiac) (HGNC Symbol)

Entrez gene summary

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.42

Chromosome location (bp)

55663137 - 55669141

Ensembl

ENSG00000129991 (version 73.37)

Entrez gene

7137

UniProt

P19429 (UniProt - Evidence at protein level)

neXtProt

NX_P19429

Antibodypedia

TNNI3 antibodies
 

PROTEIN VIEW

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TNNI3-001
 
TNNI3-005
 
TNNI3-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNNI3-001 ENSP00000341838
ENST00000344887
P19429
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Show » Show » 210 24 No 0
TNNI3-005 ENSP00000465258
ENST00000586858
K7EJP0
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57 6.4 No 0
TNNI3-006 ENSP00000466729
ENST00000588882
K7EN02
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Show » 185 21.3 No 0