KCNA5

GENE INFORMATION

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Gene name

KCNA5 (HGNC Symbol)

Synonyms

HK2, HPCN1, Kv1.5

Description

potassium voltage-gated channel, shaker-related subfamily, member 5 (HGNC Symbol)

Entrez gene summary

Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

Chromosome

12 (Chromosome progress)

Cytoband

p13.32

Chromosome location (bp)

5153085 - 5155949

Ensembl

ENSG00000130037 (version 73.37)

Entrez gene

3741

UniProt

P22460 (UniProt - Evidence at protein level)

neXtProt

NX_P22460

Antibodypedia

KCNA5 antibodies
 

PROTEIN VIEW

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KCNA5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNA5-001 ENSP00000252321
ENST00000252321
P22460
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