APOE

GENE INFORMATION

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Gene name

APOE (HGNC Symbol)

Synonyms

AD2

Description

Apolipoprotein E (HGNC Symbol)

Entrez gene summary

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

45409011 - 45412650

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130203 (version 75.37)

Entrez gene

348

UniProt

P02649 (UniProt - Evidence at protein level)

neXtProt

NX_P02649

Antibodypedia

APOE antibodies
 

PROTEIN VIEW

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APOE-001
 
APOE-002
 
APOE-004
 
APOE-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOE-001 ENSP00000252486
ENST00000252486
P02649
Show all »
Show » Show » 317 36.2 Yes 0
APOE-002 ENSP00000413135
ENST00000446996
E9PEV4
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Show » Show » 216 24.6 Yes 0
APOE-004 ENSP00000413653
ENST00000434152
H0Y7L5
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Show » Show » 269 30.6 Yes 0
APOE-005 ENSP00000410423
ENST00000425718
E7ERP7
Show all »
Show » Show » 219 24.9 Yes 0