CYP2E1

GENE INFORMATION

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Gene name

CYP2E1 (HGNC Symbol)

Synonyms

CYP2E

Description

cytochrome P450, family 2, subfamily E, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q26.3

Chromosome location (bp)

135333910 - 135374724

Ensembl

ENSG00000130649 (version 73.37)

Entrez gene

1571

UniProt

P05181 (UniProt - Evidence at protein level)

neXtProt

NX_P05181

Antibodypedia

CYP2E1 antibodies
 

PROTEIN VIEW

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CYP2E1-001
 
CYP2E1-006
 
CYP2E1-007
 
CYP2E1-008
 
CYP2E1-010
 
CYP2E1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP2E1-001 ENSP00000440689
ENST00000463117
P05181
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Show » Show » 493 56.8 Yes 0
CYP2E1-006 ENSP00000444958
ENST00000541080
Q573H0
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43 4.6 No 0
CYP2E1-007 ENSP00000412754
ENST00000421586
H0Y7H4
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Show » Show » 356 41.3 No 0
CYP2E1-008 ENSP00000397299
ENST00000418356
H0Y593
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Show » Show » 306 35.5 No 0
CYP2E1-010 ENSP00000437799
ENST00000541261
F5H694
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Show » Show » 86 9.7 Yes 0
CYP2E1-201 ENSP00000252945
ENST00000252945
P05181
Show all »
Show » Show » 493 56.8 Yes 0