PAK4

GENE INFORMATION

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Gene name

PAK4

Synonyms

Description

p21 protein (Cdc42/Rac)-activated kinase 4 (HGNC Symbol)

Entrez gene summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

39616410 - 39673456

Ensembl

ENSG00000130669 (version 73.37)

Entrez gene

10298

UniProt

O96013 (UniProt - Evidence at protein level)

neXtProt

NX_O96013

Antibodypedia

PAK4 antibodies
 

PROTEIN VIEW

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 « 
 
PAK4-001
 
PAK4-003
 
PAK4-004
 
PAK4-005
 
PAK4-006
 
PAK4-007
 
PAK4-010
 
PAK4-011
 
PAK4-015
 
PAK4-201
 
PAK4-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAK4-001 ENSP00000470284
ENST00000599470
O96013
Show all »
Show » Show » 438 48.3 No 0
PAK4-003 ENSP00000351049
ENST00000358301
O96013
Show all »
Show » Show » 591 64.1 No 0
PAK4-004 ENSP00000469413
ENST00000593690
O96013
Show all »
Show » Show » 591 64.1 No 0
PAK4-005 ENSP00000471318
ENST00000602004
M0R0L9
Show all »
182 19.6 No 0
PAK4-006 ENSP00000473215
ENST00000599657
M0R3G6
Show all »
93 10.1 No 0
PAK4-007 ENSP00000472061
ENST00000597715
Show » Show » 149 16.9 No 0
PAK4-010 ENSP00000472862
ENST00000593480
M0R2X4
Show all »
131 14.5 No 0
PAK4-011 ENSP00000326864
ENST00000321944
O96013
Show all »
Show » Show » 501 54.9 No 0
PAK4-015 ENSP00000471157
ENST00000599386
O96013
Show all »
Show » Show » 438 48.3 No 0
PAK4-201 ENSP00000353625
ENST00000360442
O96013
Show all »
Show » Show » 591 64.1 No 0
PAK4-202 ENSP00000392753
ENST00000435673
O96013
Show all »
Show » Show » 591 64.1 No 0