ATG4D

GENE INFORMATION

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Gene name

ATG4D (HGNC Symbol)

Synonyms

APG4-D, APG4D, AUTL4

Description

autophagy related 4D, cysteine peptidase (HGNC Symbol)

Entrez gene summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

19 (Chromosome progress)

Cytoband

p13.2

Chromosome location (bp)

10654571 - 10664094

Ensembl

ENSG00000130734 (version 73.37)

Entrez gene

84971

UniProt

Q86TL0 (UniProt - Evidence at protein level)

neXtProt

NX_Q86TL0

Antibodypedia

ATG4D antibodies
 

PROTEIN VIEW

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 « 
 
ATG4D-001
 
ATG4D-002
 
ATG4D-003
 
ATG4D-005
 
ATG4D-006
 
ATG4D-007
 
ATG4D-008
 
ATG4D-009
 
ATG4D-010
 
ATG4D-011
 
ATG4D-012
 
ATG4D-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATG4D-001 ENSP00000311318
ENST00000309469
Q86TL0
Show all »
Show » Show » 474 52.9 No 0
ATG4D-002 ENSP00000467906
ENST00000586417
K7EQN3
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160 16.2 No 0
ATG4D-003 ENSP00000468290
ENST00000588857
K7ERK1
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Show » 334 36.8 No 0
ATG4D-005 ENSP00000467407
ENST00000588667
K7EPJ0
Show all »
Show » 228 25.5 No 0
ATG4D-006 ENSP00000466439
ENST00000589753
K7EMB9
Show all »
Show » 67 7.4 No 0
ATG4D-007 ENSP00000467223
ENST00000586477
K7EP43
Show all »
Show » 209 23.3 No 0
ATG4D-008 ENSP00000465089
ENST00000586863
177 19.9 No 0
ATG4D-009 ENSP00000468780
ENST00000587256
203 22.7 No 0
ATG4D-010 ENSP00000466759
ENST00000588972
K7EN30
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Show » Show » 177 19.7 No 0
ATG4D-011 ENSP00000467694
ENST00000585437
K7EQ67
Show all »
Show » 99 11.3 No 0
ATG4D-012 ENSP00000465716
ENST00000585752
K7EKP6
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120 13.2 No 0
ATG4D-201 ENSP00000441375
ENST00000540862
Q969K0
Show all »
Show » 141 16 No 0