UBA1

GENERAL INFORMATION

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Gene name

UBA1

Gene description

Ubiquitin-like modifier activating enzyme 1

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in a majority of tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 3 antibodies.
HPA000289 , CAB019435 , CAB073410
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UBA1 (HGNC Symbol)

Synonyms

A1S9T, CFAP124, GXP1, POC20, UBE1, UBE1X

Description

Ubiquitin-like modifier activating enzyme 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p11.3

Chromosome location (bp)

47190861 - 47215128

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130985 (version 78.38)

Entrez gene

7317

UniProt

P22314 (UniProt - Evidence at protein level)

neXtProt

NX_P22314

Antibodypedia

UBA1 antibodies


PROTEIN BROWSER

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ENST00000335972
 
ENST00000377269
 
ENST00000377351
 
ENST00000412206
 
ENST00000427561
 
ENST00000442035
 
ENST00000451702
 
ENST00000457753
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBA1-001 ENSP00000338413
ENST00000335972
P22314
Show all »
Show » Show » 1058 117.8 No 1
UBA1-002 ENSP00000366568
ENST00000377351
P22314
Show all »
Show » Show » 1058 117.8 No 1
UBA1-003 ENSP00000366481
ENST00000377269
Q5JRR6
Show all »
Show » Show » 506 56.9 No 1
UBA1-004 ENSP00000415033
ENST00000412206
Q5JRR9
Show all »
Show » Show » 271 29.2 No 0
UBA1-005 ENSP00000397816
ENST00000427561
Q5JRS1
Show all »
Show » Show » 173 18.6 No 0
UBA1-006 ENSP00000404796
ENST00000457753
Q5JRS3
Show all »
Show » Show » 195 20.7 No 0
UBA1-007 ENSP00000389583
ENST00000442035
Q5JRS0
Show all »
Show » Show » 284 30.8 No 0
UBA1-008 ENSP00000401101
ENST00000451702
Q5JRS2
Show all »
Show » Show » 234 25.1 No 0