AKAP12

GENE INFORMATION

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Gene name

AKAP12 (HGNC Symbol)

Synonyms

AKAP250, SSeCKS

Description

A kinase (PRKA) anchor protein 12 (HGNC Symbol)

Entrez gene summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

6 (Chromosome progress)

Cytoband

q25.1

Chromosome location (bp)

151561134 - 151679692

Ensembl

ENSG00000131016 (version 73.37)

Entrez gene

9590

UniProt

Q02952 (UniProt - Evidence at protein level)

neXtProt

NX_Q02952

Antibodypedia

AKAP12 antibodies
 

PROTEIN VIEW

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AKAP12-001
 
AKAP12-002
 
AKAP12-201
 
AKAP12-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKAP12-001 ENSP00000253332
ENST00000253332
Q02952
Show all »
Show » Show » 1782 191.5 No 0
AKAP12-002 ENSP00000346702
ENST00000354675
Q02952
Show all »
Show » Show » 1684 181.7 No 0
AKAP12-201 ENSP00000352794
ENST00000359755
Q02952
Show all »
Show » Show » 1677 181 No 0
AKAP12-202 ENSP00000384537
ENST00000402676
Q02952
Show all »
Show » Show » 1782 191.5 No 0