LATS1

GENE INFORMATION

? »

Gene name

LATS1 (HGNC Symbol)

Synonyms

WARTS

Description

large tumor suppressor kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

6 (Chromosome progress)

Cytoband

q25.1

Chromosome location (bp)

149979289 - 150039392

Ensembl

ENSG00000131023 (version 73.37)

Entrez gene

9113

UniProt

O95835 (UniProt - Evidence at protein level)

neXtProt

NX_O95835

Antibodypedia

LATS1 antibodies
 

PROTEIN VIEW

? »
 
 
 
LATS1-001
 
LATS1-002
 
LATS1-003
 
LATS1-004
 
LATS1-005
 
LATS1-007
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LATS1-001 ENSP00000437550
ENST00000543571
O95835
Show all »
Show » Show » 1130 126.9 No 0
LATS1-002 ENSP00000444535
ENST00000542720
Q6PJG3
Show all »
135 15.3 No 0
LATS1-003 ENSP00000444678
ENST00000392273
O95835
Show all »
Show » Show » 690 76.2 No 0
LATS1-004 ENSP00000403815
ENST00000441107
Q6PJG3
Show all »
135 15.3 No 0
LATS1-005 ENSP00000253339
ENST00000253339
O95835
Show all »
Show » Show » 1130 126.9 No 0
LATS1-007 ENSP00000441265
ENST00000458696
H0YG09
Show all »
Show » 201 21.4 No 0