COX4I2

GENERAL INFORMATION

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Gene name

COX4I2

Gene description

Cytochrome c oxidase subunit IV isoform 2 (lung)

Protein class

Disease related genes
Mitochondrial proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in selected tissues, most abundant in placenta and lung. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA029307
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

COX4I2 (HGNC Symbol)

Synonyms

COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2

Description

Cytochrome c oxidase subunit IV isoform 2 (lung) (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

q11.21

Chromosome location (bp)

31637888 - 31645006

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131055 (version 78.38)

Entrez gene

84701

UniProt

Q96KJ9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96KJ9

Antibodypedia

COX4I2 antibodies


PROTEIN BROWSER

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ENST00000376075
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX4I2-001 ENSP00000365243
ENST00000376075
Q96KJ9
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