EDA2R

GENERAL INFORMATION

? »

Gene name

EDA2R

Gene description

Ectodysplasin A2 receptor

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Normal tissues displayed weak to moderate cytoplasmic positivity. Distinct positivity was observed in blood plasma. Urinary epithelium, Leydig cells and a subset of cells in lymphoid tissues showed strong cytoplasmic and membranous staining. Cells of the CNS, liver, pancreas, myocytes, thyroid and parathyroid glands were negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB015945
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

? »

Gene name

EDA2R (HGNC Symbol)

Synonyms

EDA-A2R, EDAA2R, TNFRSF27, XEDAR

Description

Ectodysplasin A2 receptor (HGNC Symbol)

Entrez gene summary

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011]

Chromosome

X

Cytoband

q12

Chromosome location (bp)

66595637 - 66639298

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131080 (version 78.38)

Entrez gene

60401

UniProt

Q9HAV5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HAV5

Antibodypedia

EDA2R antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000253392
 
ENST00000374719
 
ENST00000396050
 
ENST00000451436
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EDA2R-001 ENSP00000363851
ENST00000374719
Q9HAV5
Show all »
Show » Show » 297 32.8 No 1
EDA2R-002 ENSP00000253392
ENST00000253392
Q9HAV5
Show all »
Show » Show » 318 35.1 No 1
EDA2R-201 ENSP00000379365
ENST00000396050
Q9HAV5
Show all »
Show » Show » 318 35.1 No 1
EDA2R-202 ENSP00000415242
ENST00000451436
Q9HAV5
Show all »
Show » Show » 297 32.8 No 1