ATP6V1E1

GENE INFORMATION

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Gene name

ATP6V1E1 (HGNC Symbol)

Synonyms

ATP6E, ATP6E2, ATP6V1E, P31, Vma4

Description

ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 (HGNC Symbol)

Entrez gene summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

18074902 - 18111584

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131100 (version 75.37)

Entrez gene

529

UniProt

P36543 (UniProt - Evidence at protein level)

neXtProt

NX_P36543

Antibodypedia

ATP6V1E1 antibodies
 

PROTEIN VIEW

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ATP6V1E1-001
 
ATP6V1E1-004
 
ATP6V1E1-005
 
ATP6V1E1-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V1E1-001 ENSP00000253413
ENST00000253413
P36543
Show all »
Show » Show » 226 26.1 No 0
ATP6V1E1-004 ENSP00000398932
ENST00000413576
C9J8H1
Show all »
Show » Show » 203 23.5 No 0
ATP6V1E1-005 ENSP00000382696
ENST00000399798
P36543
Show all »
Show » Show » 204 23.6 No 0
ATP6V1E1-006 ENSP00000382694
ENST00000399796
P36543
Show all »
Show » Show » 196 22.7 No 0