COX7B

GENERAL INFORMATION

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Gene name

COX7B

Gene description

Cytochrome c oxidase subunit VIIb

Protein class

Disease related genes
Mitochondrial proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Neuronal cells showed strong cytoplasmic and nuclear positivity. Heart myocytes displayed strong cytoplasmic positivity. Weak to moderate staining was observed in upper stomach, small intestine, gall bladder, parathyroid gland and renal tubules. Remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA058041
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

COX7B

Synonyms

Description

Cytochrome c oxidase subunit VIIb (HGNC Symbol)

Entrez gene summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]

Chromosome

X

Cytoband

q21.1

Chromosome location (bp)

77899438 - 77907373

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131174 (version 78.38)

Entrez gene

1349

UniProt

P24311 (UniProt - Evidence at protein level)

neXtProt

NX_P24311

Antibodypedia

COX7B antibodies


PROTEIN BROWSER

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ENST00000481445
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COX7B-001 ENSP00000417656
ENST00000481445
P24311
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