IDO1

GENE INFORMATION

? »

Gene name

IDO1 (HGNC Symbol)

Synonyms

IDO, INDO

Description

indoleamine 2,3-dioxygenase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Chromosome

8 (Chromosome progress)

Cytoband

p11.21

Chromosome location (bp)

39759794 - 39785963

Ensembl

ENSG00000131203 (version 73.37)

Entrez gene

3620

UniProt

P14902 (UniProt - Evidence at protein level)

neXtProt

NX_P14902

Antibodypedia

IDO1 antibodies
 

PROTEIN VIEW

? »
 
 
 
IDO1-001
 
IDO1-002
 
IDO1-003
 
IDO1-004
 
IDO1-005
 
IDO1-008
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IDO1-001 ENSP00000430950
ENST00000518237
P14902
Show all »
Show » Show » 403 45.3 No 0
IDO1-002 ENSP00000253513
ENST00000253513
J3KN03
Show all »
Show » 170 20 No 0
IDO1-003 ENSP00000429297
ENST00000518804
E5RIX2
Show all »
Show » 78 9.2 No 0
IDO1-004 ENSP00000429933
ENST00000522840
E5RH36
Show all »
Show » 47 5.6 No 0
IDO1-005 ENSP00000430505
ENST00000522495
P14902
Show all »
Show » Show » 403 45.3 No 0
IDO1-008 ENSP00000428716
ENST00000519154
E5RGR8
Show all »
Show » 180 20.6 No 0