ACLY

GENE INFORMATION

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Gene name

ACLY (HGNC Symbol)

Synonyms

ACL, ATPCL, CLATP

Description

ATP citrate lyase (HGNC Symbol)

Entrez gene summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

40023161 - 40086795

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131473 (version 75.37)

Entrez gene

47

UniProt

P53396 (UniProt - Evidence at protein level)

neXtProt

NX_P53396

Antibodypedia

ACLY antibodies
 

PROTEIN VIEW

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ACLY-001
 
ACLY-002
 
ACLY-003
 
ACLY-004
 
ACLY-005
 
ACLY-006
 
ACLY-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACLY-001 ENSP00000253792
ENST00000352035
P53396
Show all »
Show » Show » 1101 120.8 No 0
ACLY-002 ENSP00000377474
ENST00000393896
P53396
Show all »
Show » Show » 1091 119.8 No 0
ACLY-003 ENSP00000466259
ENST00000590151
P53396
Show all »
Show » Show » 1101 120.8 No 0
ACLY-004 ENSP00000445349
ENST00000537919
B4E3P0
Show all »
Show » Show » 830 91.1 No 0
ACLY-005 ENSP00000468705
ENST00000592970
K7ESG8
Show all »
Show » Show » 109 12.3 No 0
ACLY-006 ENSP00000464717
ENST00000590770
K7EIE7
Show all »
Show » Show » 133 14.2 No 0
ACLY-201 ENSP00000345398
ENST00000353196
P53396
Show all »
Show » Show » 1091 119.8 No 0