AOC2

GENE INFORMATION

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Gene name

AOC2 (HGNC Symbol)

Synonyms

DAO2, RAO

Description

amine oxidase, copper containing 2 (retina-specific) (HGNC Symbol)

Entrez gene summary

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.31

Chromosome location (bp)

40996617 - 41002724

Ensembl

ENSG00000131480 (version 73.37)

Entrez gene

314

UniProt

O75106 (UniProt - Evidence at protein level)

neXtProt

NX_O75106

Antibodypedia

AOC2 antibodies
 

PROTEIN VIEW

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AOC2-001
 
AOC2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AOC2-001 ENSP00000253799
ENST00000253799
O75106
Show all »
Show » Show » 756 83.7 Yes 0
AOC2-002 ENSP00000406134
ENST00000452774
O75106
Show all »
Show » Show » 729 80.5 Yes 0