ACACA

GENE INFORMATION

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Gene name

ACACA (HGNC Symbol)

Synonyms

ACAC, ACC, ACC1

Description

acetyl-CoA carboxylase alpha (HGNC Symbol)

Entrez gene summary

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

35441923 - 35766909

Ensembl

ENSG00000132142 (version 73.37)

Entrez gene

31

UniProt

Q13085 (UniProt - Evidence at protein level)

neXtProt

NX_Q13085

Antibodypedia

ACACA antibodies
 

PROTEIN VIEW

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 « 
 
ACACA-001
 
ACACA-002
 
ACACA-003
 
ACACA-004
 
ACACA-005
 
ACACA-007
 
ACACA-008
 
ACACA-009
 
ACACA-010
 
ACACA-012
 
ACACA-013
 
ACACA-018
 
ACACA-019
 
ACACA-024
 
ACACA-025
 
ACACA-201
 
ACACA-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACACA-001 ENSP00000344789
ENST00000353139
Q13085
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Show » Show » 2383 270 No 0
ACACA-002 ENSP00000353898
ENST00000360679
Q13085
Show all »
Show » Show » 2288 259.7 No 0
ACACA-003 ENSP00000335323
ENST00000335166
Q13085
Show all »
Show » Show » 2268 257.2 No 0
ACACA-004 ENSP00000397282
ENST00000451642
Q13085
Show all »
Show » Show » 120 13.1 No 0
ACACA-005 ENSP00000391737
ENST00000413318
A8MYL5
Show all »
Show » 42 4.7 No 0
ACACA-007 ENSP00000391001
ENST00000456561
84 9 No 0
ACACA-008 ENSP00000377925
ENST00000394403
A8MYL5
Show all »
Show » 42 4.7 No 0
ACACA-009 ENSP00000377928
ENST00000394406
Q13085
Show all »
Show » Show » 2346 265.6 No 0
ACACA-010 ENSP00000390132
ENST00000456066
D3YTK0
Show all »
114 12.7 No 0
ACACA-012 ENSP00000467820
ENST00000591119
Q59FY4
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Show » Show » 998 114.6 No 0
ACACA-013 ENSP00000467354
ENST00000587233
52 6.2 No 0
ACACA-018 ENSP00000464763
ENST00000591148
K7EII5
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Show » 94 10.8 No 0
ACACA-019 ENSP00000464991
ENST00000588142
K7EJ22
Show all »
112 12.1 No 0
ACACA-024 ENSP00000465478
ENST00000592427
K7EK64
Show all »
Show » 235 26.7 No 0
ACACA-025 ENSP00000466486
ENST00000586821
96 10.6 No 0
ACACA-201 ENSP00000354565
ENST00000361253
K4DID9
Show all »
Show » 472 54.1 No 0
ACACA-202 ENSP00000399445
ENST00000416895
D3YTK0
Show all »
77 8.3 No 0