RAF1

GENE INFORMATION

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Gene name

RAF1 (HGNC Symbol)

Synonyms

c-Raf, CRAF, Raf-1

Description

v-raf-1 murine leukemia viral oncogene homolog 1 (HGNC Symbol)

Entrez gene summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p25.2

Chromosome location (bp)

12625100 - 12705725

Ensembl

ENSG00000132155 (version 73.37)

Entrez gene

5894

UniProt

P04049 (UniProt - Evidence at protein level)

neXtProt

NX_P04049

Antibodypedia

RAF1 antibodies
 

PROTEIN VIEW

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RAF1-001
 
RAF1-006
 
RAF1-007
 
RAF1-008
 
RAF1-010
 
RAF1-201
 
RAF1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAF1-001 ENSP00000251849
ENST00000251849
P04049
Show all »
Show » Show » 648 73.1 No 0
RAF1-006 ENSP00000401088
ENST00000423275
69 7.7 No 0
RAF1-007 ENSP00000401888
ENST00000442415
P04049
Show all »
Show » Show » 668 75.4 No 0
RAF1-008 ENSP00000398591
ENST00000432427
H7C155
Show all »
Show » 527 59.7 No 0
RAF1-010 ENSP00000391265
ENST00000416093
69 7.7 No 0
RAF1-201 ENSP00000441186
ENST00000534997
B4E1N6
Show all »
Show » 433 48.9 No 0
RAF1-202 ENSP00000443567
ENST00000542177
B4E0X2
Show all »
Show » 567 64 No 0