PRKAA1

GENE INFORMATION

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Gene name

PRKAA1 (HGNC Symbol)

Synonyms

AMPKa1

Description

protein kinase, AMP-activated, alpha 1 catalytic subunit (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

p13.1

Chromosome location (bp)

40759481 - 40798476

Ensembl

ENSG00000132356 (version 73.37)

Entrez gene

5562

UniProt

Q13131 (UniProt - Evidence at protein level)

neXtProt

NX_Q13131

Antibodypedia

PRKAA1 antibodies
 

PROTEIN VIEW

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PRKAA1-001
 
PRKAA1-002
 
PRKAA1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKAA1-001 ENSP00000346148
ENST00000354209
Q13131
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Show » Show » 574 65.5 No 0
PRKAA1-002 ENSP00000380317
ENST00000397128
Q13131
Show all »
Show » Show » 559 64 No 0
PRKAA1-003 ENSP00000296800
ENST00000296800
Q96E92
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Show » 207 23.6 No 0