CASP9

GENE INFORMATION

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Gene name

CASP9 (HGNC Symbol)

Synonyms

APAF-3, ICE-LAP6, MCH6, PPP1R56

Description

caspase 9, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

1 (Chromosome progress)

Cytoband

p36.21

Chromosome location (bp)

15817327 - 15853029

Ensembl

ENSG00000132906 (version 73.37)

Entrez gene

842

UniProt

P55211 (UniProt - Evidence at protein level)

neXtProt

NX_P55211

Antibodypedia

CASP9 antibodies
 

PROTEIN VIEW

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CASP9-001
 
CASP9-002
 
CASP9-003
 
CASP9-005
 
CASP9-006
 
CASP9-007
 
CASP9-008
 
CASP9-009
 
CASP9-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP9-001 ENSP00000330237
ENST00000333868
P55211
Show all »
Show » Show » 416 46.3 No 0
CASP9-002 ENSP00000255256
ENST00000348549
P55211
Show all »
Show » Show » 266 30.2 No 0
CASP9-003 ENSP00000396540
ENST00000447522
Q5JRU2
Show all »
Show » 266 28.8 No 0
CASP9-005 ENSP00000411304
ENST00000440484
Q5JRU8
Show all »
Show » 254 28.4 No 0
CASP9-006 ENSP00000383588
ENST00000400777
Show » 152 17 No 0
CASP9-007 ENSP00000408691
ENST00000424908
Show » 198 21.8 No 0
CASP9-008 ENSP00000365051
ENST00000375890
P55211
Show all »
Show » Show » 333 36.6 No 0
CASP9-009 ENSP00000449584
ENST00000546424
F8VVS7
Show all »
Show » 421 46.5 No 0
CASP9-011 ENSP00000449216
ENST00000474305
F8VWA5
Show all »
Show » 95 11.1 No 0