CDK8

GENE INFORMATION

? »

Gene name

CDK8 (HGNC Symbol)

Synonyms

K35

Description

cyclin-dependent kinase 8 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]

Chromosome

13 (Chromosome progress)

Cytoband

q12.13

Chromosome location (bp)

26828276 - 26979375

Ensembl

ENSG00000132964 (version 73.37)

Entrez gene

1024

UniProt

P49336 (UniProt - Evidence at protein level)

neXtProt

NX_P49336

Antibodypedia

CDK8 antibodies
 

PROTEIN VIEW

? »
 
 
 
CDK8-001
 
CDK8-201
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDK8-001 ENSP00000370938
ENST00000381527
P49336
Show all »
Show » Show » 464 53.3 No 0
CDK8-201 ENSP00000437696
ENST00000536792
F5H6D4
Show all »
Show » 164 19.3 No 0