ALOX5AP

GENE INFORMATION

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Gene name

ALOX5AP (HGNC Symbol)

Synonyms

FLAP

Description

arachidonate 5-lipoxygenase-activating protein (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Chromosome

13 (Chromosome progress)

Cytoband

q12.3

Chromosome location (bp)

31309645 - 31338556

Ensembl

ENSG00000132965 (version 73.37)

Entrez gene

241

UniProt

P20292 (UniProt - Evidence at protein level)

neXtProt

NX_P20292

Antibodypedia

ALOX5AP antibodies
 

PROTEIN VIEW

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ALOX5AP-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ALOX5AP-001 ENSP00000369858
ENST00000380490
P20292
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