CHIT1

GENE INFORMATION

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Gene name

CHIT1 (HGNC Symbol)

Synonyms

CHI3, CHIT

Description

chitinase 1 (chitotriosidase) (HGNC Symbol)

Entrez gene summary

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

Chromosome

1 (Chromosome progress)

Cytoband

q32.1

Chromosome location (bp)

203181955 - 203242769

Ensembl

ENSG00000133063 (version 73.37)

Entrez gene

1118

UniProt

Q13231 (UniProt - Evidence at protein level)

neXtProt

NX_Q13231

Antibodypedia

CHIT1 antibodies
 

PROTEIN VIEW

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CHIT1-001
 
CHIT1-002
 
CHIT1-006
 
CHIT1-007
 
CHIT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHIT1-001 ENSP00000356198
ENST00000367229
Q13231
Show all »
Show » Show » 466 51.7 Yes 0
CHIT1-002 ENSP00000423778
ENST00000491855
Q13231
Show all »
Show » Show » 387 43.1 Yes 0
CHIT1-006 ENSP00000421617
ENST00000503786
D6REY1
Show all »
Show » Show » 361 40.2 Yes 0
CHIT1-007 ENSP00000255427
ENST00000255427
Q13231
Show all »
Show » Show » 447 49.6 Yes 0
CHIT1-201 ENSP00000438078
ENST00000535569
G5EA51
Show all »
Show » Show » 457 50.6 Yes 0