DCLK1

GENE INFORMATION

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Gene name

DCLK1 (HGNC Symbol)

Synonyms

DCAMKL1, DCDC3A, DCLK, KIAA0369

Description

doublecortin-like kinase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

Chromosome

13 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

36345478 - 36705443

Ensembl

ENSG00000133083 (version 73.37)

Entrez gene

9201

UniProt

O15075 (UniProt - Evidence at protein level)

neXtProt

NX_O15075

Antibodypedia

DCLK1 antibodies
 

PROTEIN VIEW

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DCLK1-001
 
DCLK1-006
 
DCLK1-010
 
DCLK1-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCLK1-001 ENSP00000369222
ENST00000379892
Q5VZY9
Show all »
Show » 363 40.5 No 0
DCLK1-006 ENSP00000255448
ENST00000255448
O15075
Show all »
Show » Show » 729 81.1 No 1
DCLK1-010 ENSP00000353846
ENST00000360631
O15075
Show all »
Show » Show » 740 82.2 No 1
DCLK1-011 ENSP00000369223
ENST00000379893
O15075
Show all »
Show » Show » 433 47.7 No 1