RTN3

GENE INFORMATION

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Gene name

RTN3 (HGNC Symbol)

Synonyms

ASYIP, HAP, NSPL2, NSPLII, RTN3-A1

Description

reticulon 3 (HGNC Symbol)

Entrez gene summary

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

Chromosome

11 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

63448918 - 63527363

Ensembl

ENSG00000133318 (version 73.37)

Entrez gene

10313

UniProt

O95197 (UniProt - Evidence at protein level)

neXtProt

NX_O95197

Antibodypedia

RTN3 antibodies
 

PROTEIN VIEW

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RTN3-001
 
RTN3-002
 
RTN3-003
 
RTN3-004
 
RTN3-005
 
RTN3-006
 
RTN3-007
 
RTN3-009
 
RTN3-010
 
RTN3-013
 
RTN3-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RTN3-001 ENSP00000344106
ENST00000339997
O95197
Show all »
Show » Show » 1013 110.7 No 2
RTN3-002 ENSP00000367050
ENST00000377819
O95197
Show all »
Show » Show » 1032 112.6 No 2
RTN3-003 ENSP00000442733
ENST00000540798
O95197
Show all »
Show » Show » 920 100.8 No 2
RTN3-004 ENSP00000440960
ENST00000536011
B7Z4M1
Show all »
Show » Show » 123 12.7 No 1
RTN3-005 ENSP00000440874
ENST00000537981
O95197
Show all »
Show » Show » 236 25.6 No 2
RTN3-006 ENSP00000346492
ENST00000354497
O95197
Show all »
Show » Show » 214 23.5 No 1
RTN3-007 ENSP00000340903
ENST00000341307
O95197
Show all »
Show » Show » 241 26.5 No 2
RTN3-009 ENSP00000442080
ENST00000543552
F5H891
Show all »
Show » 130 13.3 No 0
RTN3-010 ENSP00000441614
ENST00000545432
F5GWG7
Show all »
Show » 136 14 No 0
RTN3-013 ENSP00000437971
ENST00000542238
F5H617
Show all »
Show » Show » 185 19.9 No 1
RTN3-201 ENSP00000348279
ENST00000356000
O95197
Show all »
Show » Show » 255 27.6 No 2