MYH11

GENE INFORMATION

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Gene name

MYH11 (HGNC Symbol)

Synonyms

SMHC, SMMHC

Description

myosin, heavy chain 11, smooth muscle (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

p13.11

Chromosome location (bp)

15796992 - 15950890

Ensembl

ENSG00000133392 (version 73.37)

Entrez gene

4629

UniProt

P35749 (UniProt - Evidence at protein level)

neXtProt

NX_P35749

Antibodypedia

MYH11 antibodies
 

PROTEIN VIEW

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MYH11-001
 
MYH11-003
 
MYH11-006
 
MYH11-013
 
MYH11-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MYH11-001 ENSP00000300036
ENST00000300036
P35749
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Show » Show » 1972 227.3 No 0
MYH11-003 ENSP00000458731
ENST00000576790
P35749
Show all »
Show » Show » 1938 223.6 No 0
MYH11-006 ENSP00000379616
ENST00000396324
P35749
Show all »
Show » Show » 1979 228.1 No 0
MYH11-013 ENSP00000407821
ENST00000452625
P35749
Show all »
Show » Show » 1945 224.3 No 0
MYH11-201 ENSP00000345136
ENST00000338282
P35749
Show all »
Show » Show » 1938 223.6 No 0