KRAS

GENE INFORMATION

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Gene name

KRAS (HGNC Symbol)

Synonyms

KRAS1, KRAS2

Description

Kirsten rat sarcoma viral oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

Chromosome

12 (Chromosome progress)

Cytoband

p12.1

Chromosome location (bp)

25357723 - 25403870

Ensembl

ENSG00000133703 (version 73.37)

Entrez gene

3845

UniProt

P01116 (UniProt - Evidence at protein level)

neXtProt

NX_P01116

Antibodypedia

KRAS antibodies
 

PROTEIN VIEW

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KRAS-001
 
KRAS-002
 
KRAS-003
 
KRAS-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRAS-001 ENSP00000308495
ENST00000311936
P01116
Show all »
Show » Show » 188 21.4 No 0
KRAS-002 ENSP00000451856
ENST00000556131
G3V4K2
Show all »
Show » Show » 43 4.7 No 0
KRAS-003 ENSP00000452512
ENST00000557334
G3V5T7
Show all »
Show » Show » 75 8.5 No 0
KRAS-004 ENSP00000256078
ENST00000256078
P01116
Show all »
Show » Show » 189 21.7 No 0