E2F5

GENE INFORMATION

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Gene name

E2F5

Synonyms

Description

E2F transcription factor 5, p130-binding (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

86089460 - 86129387

Ensembl

ENSG00000133740 (version 73.37)

Entrez gene

1875

UniProt

Q15329 (UniProt - Evidence at protein level)

neXtProt

NX_Q15329

Antibodypedia

E2F5 antibodies
 

PROTEIN VIEW

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E2F5-001
 
E2F5-002
 
E2F5-003
 
E2F5-004
 
E2F5-005
 
E2F5-006
 
E2F5-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

E2F5-001 ENSP00000398124
ENST00000416274
Q15329
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Show » Show » 346 37.6 No 0
E2F5-002 ENSP00000414312
ENST00000418930
Q15329
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Show » Show » 345 37.5 No 0
E2F5-003 ENSP00000428606
ENST00000521429
E5RHD4
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173 18.7 Yes 0
E2F5-004 ENSP00000429120
ENST00000517476
Q15329
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Show » Show » 185 20.2 No 0
E2F5-005 ENSP00000430461
ENST00000520225
Show » 130 13.9 No 1
E2F5-006 ENSP00000429669
ENST00000518234
H0YBK0
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182 19.8 No 0
E2F5-201 ENSP00000256117
ENST00000256117
C9JYE9
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Show » Show » 347 37.7 No 0