SORT1

GENE INFORMATION

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Gene name

SORT1 (HGNC Symbol)

Synonyms

Gp95, NT3

Description

sortilin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]

Chromosome

1 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

109852192 - 109940573

Ensembl

ENSG00000134243 (version 73.37)

Entrez gene

6272

UniProt

Q99523 (UniProt - Evidence at protein level)

neXtProt

NX_Q99523

Antibodypedia

SORT1 antibodies
 

PROTEIN VIEW

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SORT1-001
 
SORT1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SORT1-001 ENSP00000256637
ENST00000256637
Q99523
Show all »
Show » Show » 831 92.1 Yes 1
SORT1-201 ENSP00000438597
ENST00000538502
Q99523
Show all »
Show » Show » 694 77.4 No 1